ABSTRACT
To investigate the effects of total glucosides of Curculigo rhizome [TGC] to perimenopausal period [PMS] mice model. After removed the bilateral ovaries induced the PMS mice model, high, medium and low doses of TGC group were partly given TGC solution 400,200,100mg·kg-1, administered once a day, continuously 21 days. Compared with the model group [MG] mices, each dose of TGC group could significantly improve the activities of mice, increase thymus, uterus, spleen index[TI, UI, SI], the levels of testosterone[T], estradiol [E[2]], reduce the level of luteinizing hormone [LH], the high dose of TGC group[HD-C] group has the best effects. It prompted that TGC has the effect in treatment of PMS mice model, the HD-C group of TGC has the best effects